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KMID : 1140920220460060320
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Annals of Rehabilitation Medicine
2022 Volume.46 No. 6 p.320 ~ p.328
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Treadmill Exercise as a Preventive Measure Against Age-Related Anxiety and Social Behavioral Disorders in Rats: When Is It Worth Starting?
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Taguchi Satoru
Choudhury Mohammed E.
Mikami Kanta
Utsunomiya Ryo
Yano Hajime
Tanaka Junya
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Abstract
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Objective : To determine the appropriate time points to start regular exercise which could reduce age-related anxiety and impaired social behavior.
Methods : For this study, 8-week-old male Wistar rats were divided into three groups: no exercise (NoEX), short-term exercise (S-Ex), and long-term exercise (L-Ex) groups. S-Ex-group rats started treadmill exercise at 12 months of age, while L-Ex rats started from at 2 months of age. Exercise rats were forced to walk on the treadmill three times per week, with 1- to 2-day intervals for 10 minutes during the first 2 weeks, at 10 m/min until 17 months of age, and at 8 m/min thereafter. At 19 months of age, behavioral tests were performed to assess the effects of exercise on age-induced behavioral change as well as quantitative polymerase chain reaction were done to uncover the mechanism behind the behavioral changes.
Results : Anxiety-like behavior was improved by long-term exercise. Additionally, rats belonging to the S-Ex and L-Ex groups showed improved social behavior and increased curiosity about interesting objects. The qPCR data showed that treadmill exercise suppressed the expression of immediate-early genes in the prefrontal cortex of the aged rats.
Conclusion : This study suggests that long-term exercise represses early response genes, and in this way, it increases resistance to stress, diminishes anxiety-related behavior, and improves social behavior. These findings underscore the need to consider appropriate time to start exercise to prevent stress induced anxiety related behavior.
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KEYWORD
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Aging, Exercise, Prefrontal cortex, Behavior, Immediate-early genes
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